Pharmacoeinetic and clinical studies of Azithromycin on otorhinolaryngological infections

BABA Shunkichi, MIYAMOTO Naoya, UNNO Tokuji, NONAKA Satoshi, KANAI Naoki, WATANABE Akihito, HAYASHI Hiroshi, KAMITO Toshihiko, ICHIKAWA Ginichiro, SAKURAI Atsushi, YAMAKAWA Takuya, ITABASHI Takatsugu, FUKAMOTO Katsuhiko, MIYAKE Hirosato, SATO Mutsumi, TAKAHASHI Hideaki, OGATA Tetsuro, YAMAZAKI Mitsuyo, SAKAI Makoto, SHINKAWA Atsushi, KIMURA Hideshige, IDEI Norio, NISHIMURA Tadao, TOKUDA Toshikazu, OKAMOTO Hirotaka, YOKOTA Akira, KATO Kaoru, KOBAYASHI Takehiro, SAKAI Kunimitsu, TSUGE Isato, MORIBE Kazuho, KAMEI Sotaro, KOUKETSU Masakazu, KITAO Shunji, KOJIMA Ken, TAKAHASHI Mariko, HONJOU Iwao, FUJITA Akihiko, KURATA Kyosuke, MATSUNAGA Toru, KUBO Takeshi, KOIZUKA Izumi, ASHIDA Kentaro, MURATA Junko, SENBA Osamu, ISHIDA Minoru, SATO Shinji, HARADA Yasuo, YAJIN Koji, SUZUKI Mamoru, HIRAKAWA Katsuhiro, TAGASHIRA Nobuharu, HIRATA Shitau, SHIRANE Makoto, KOBAYASHI Yuko, NAGASAWA Hiroshi, OHYAMA Masaru, FURUTA Shigeru, MATSUZAKI Tsutomu, KIYOTA Ryuji, OHNO Fumio, DEGUCHI Koji, YANO Hiromi, HARAGUCHI Kaneaki, SHIBA Koya, SAITO Atsushi, SHIMADA Kaoru

doi:10.11334/jibi1954.41.6_946

Pharmacokinetic and clinical studies were carried out to evaluate the effectiveness and safety of azithromycin (AZM) for the treatment of otorhinolaryngological infections. The results were as follows: The distribution of AZM to both the humor and tissue was good, in Particular, in the tympanium mucosa, tonsils, maxillary sinus mucosa, ethmodial sinus mucosa and submandibular gland. In addition, these tissue concentrations were also maintained for a long period of time. AZM was orally administered to 180 patients, and most received 250 mg or 500 mg daily for 3 days. The clinical efficacy rates, evaluated in 139 patients, were 73% for otitis media, 77% for sinusitis, 79% for tonsillitis and 74% for pharyngolaryngitis, with an overall efficacy rate of 76%. The bacteriological efficacy rates were, based on the eradication rete, 90% for monobacterial infections caused by Gram-positive organisms, 89% for monobacterial infections caused by Gram-negative orgamisms and 77% for polybacterial infections, while the overall eradication rate was 85%. Side effects were observed in 1 patient (1%) out of 170 patients, while clinical laboratory abnormalities were observed in 8 patients (6%) out of 131 patients who underwent clinical laboratory tests after treatment. Based on the above results, AZM was found to be highly useful for the treatnment of various otorhinolaryngological infections such as otitis media, sinusitis, tonsillitis and pharyngoloryngitis.

Pharmacoeinetic and clinical studies of Azithromycin on otorhinolaryngological infections

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