Clinical Study of Isosorbide on Meniere's Disease
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- KITAHARA Masaaki
- Department of Otorhinolaryngology, Shiga University of Medical Science
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- WATANABE Isamu
- Department of Otolaryngology, Tokyo Medical and Dental University, School of Medicine
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- HINOKI Manabi
- Shimane Medical University
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- MIZUKOSHI Kanemasa
- Department of Otolaryngology, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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- MATSUNAGA Toru
- Department of Otorhinolaryngology, Osaka University, School of Medicine
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- MATSUNAGA Takashi
- Department of Otorhinolaryngology, Nara Medical College
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- KOMATSUZAKI Atsushi
- Department of Otorhinolaryngology, School of Medicine, Toho University
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- MATSUOKA IZURU
- Department of Otorhinolaryngology, Eaculty of Medicine, Kyoto University
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- UEMURA Takuya
- Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University
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- MORIMITSU Tamotsu
- Department of Otorhinolaryngology, Miyazaki Medical College
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- ISHII Tetsuo
- Department of Otorhinolaryngology, Tokyo Women's Medical College
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- KUMOI Takeo
- Department of Otorhinolaryngology, Hyogo College of Medicine
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- SHIRABE Shigeaki
- Department of Otorhinolaryngology, School of Medicine, Fukuoka University
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- NAKAJIMA Shigeto
- Department of Otolaryngology, School of Medicine, Nagasaki University
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- FUTAKI Takashi
- Department of Otolaryngology, University of Tokyo
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- YAMAKAWA Munetaka
- Department of Otolaryngology, Hokkaido University, School of Medicine
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- KIKUCHI Naoko
- Department of Otorhinolaryngology, Tokyo Women's Medical College
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- INAMORI Toru
- Department of Otorhinolaryngology, Hyogo College of Medicine
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- OGINO Hitoshi
- Department of Otorhinolaryngology, Osaka University, School of Medicine
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- KAKIUCHI Hisami
- Department of Otorhinolaryngology, Nara Medical College
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- MAJIMA Kazuhiko
- Department of Otolaryngology, Tokyo Medical and Dental University, School of Medicine
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- OGAWA Nobuya
- Department of Pharmacology, Ehime University, School of Medicine
Bibliographic Information
- Other Title
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- Isosorbideのメニエール病に対する効果に関する臨床的検討
- Inter-group Comparative Study with Betahistine Mesylate by Multi-centered Double-blind Trial
- 多施設二重盲検法によるBetahistine Mesylateとの群間比較
Abstract
Clinical effect of Isosorbide (ISO) was studied in patients with Meniere's disease from their subjective symptoms and objective findings by multi-centered double-blind trial with Betahistine Mesylate (BM) as a reference drug. 1) Global improvement rating: ISO-treated group was more superior than BM-treated group in 2 weeks and 4 weeks after administration with a statistically significant difference (P<0.05) in Wilcoxon test when statistical analysis was made based on the judgement by investigators, however, there was no statistically significant difference between both groups when analyzed based on the judgement by the Committee. 2) Utility rate: Upon the judgement by investigators, ISO-treated group was more superior than BM-treated group in 2 weeks and 4 weeks after administration with a tendency of statistical difference in Wilcoxon test, however, there was no statistically significant difference between both groups upon the judgement by the Committee. 3) Side effect, clinical laboratory test and safety rate: There was no particular difference between both groups. From the above results, it was concluded that ISO was an effective and useful drug for Meniere's disease.
Journal
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- OTOLOGIA FUKUOKA
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OTOLOGIA FUKUOKA 32 (1), 44-92, 1986-01-20
JIBI TO RINSHO KAI
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Keywords
Details 詳細情報について
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- CRID
- 1390282680476098560
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- NII Article ID
- 130004403124
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- ISSN
- 04477227
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed