A Scanning Electron Microscopic Study on the Human Cochlea after Treatment with Cisplatinum

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  • FUJINO Akito
    Department of Otorhinolaryngology, Sagamihara National Hospital
  • IKEGAMI Akihiro
    Department of Otorhinolaryngology, Sagamihara National Hospital
  • OKAMOTO Makito
    Department of Otorhinolaryngology, Sagamihara National Hospital
  • SHITARA Tetsuya
    Department of Otorhinolaryngology, School of Medicine, Kitasato University

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  • シスプラチンを投与されたヒト蝸牛の走査電顕的観察

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Abstract

A 49-year-old male with a soft palate neoplasm was treated with Cisplatinum. Cisplatinum was given intravenously for a period of 5 months with a total dose of 600 mg. The patient died 3.5 months after the treatment. Morphological study of the organ of Corti was conducted by scanning electron microscopy. The following findings were observed. 1) Although loss of hair cells was seen sporadically, the damage was severest in the lower turn. 2) Outer hair cells were more severely damaged than inner hair cells. 3) The first row of the outer hair cells tended to be more severely damaged. 4) Supporting cells were also damaged.

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