Combined effect of Norfloxacin and Carbocisteine on paranasal sinusitis

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  • 副鼻腔炎に対するノルフロキサシン (NFLX) とカルボシステイン (SCMC) 併用効果の検討

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The combined effect of norfloxacin (NFLX) and carbocisteine (SCMC) on paranasal sinusitis was examined. Cases with acute paranasal sinusitis and acute exacerbation of chronic paranasal sinusitis were randomly divided into two groups. One group (38 cases) was administered NFLX alone 600mg/day p. o. for 14 days. The other group (36 cases) was treated with the combination of NFLX 600mg/day and SCMC 1500mg/day p. o. for 14 days. The following results were obtained.<BR>1. The overall clinical efficacy rate (cases of remarkably and moderately effective) was 66% in the NFLX alone group and 86% in the combined group. The effect of the combined group surpassed that of the NFLX alone group, especially in chronic cases.<BR>2. The overall effect on the nature of nasal discharge was observed in 73% of cases in the NFLX alone group and in 86% of the combined group. The overall effect on the volume of nasal discharge was observed in 84% of cases in the NFLX alone group and in 91% of the combined group. The combined therapy of NFLX and SCMC was found to be superior to that of NFLX alone for the improvement of the nature and volume of nasal discharge. These results indicate that combined therapy with NFLX and SCMC is a more useful therapeutic method for the treatment of paranasal sinusitis.

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