Individuality and Genetic Effect on Experimental Atherosclerosis in Rabbits

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  • ウサギの実験的動脈硬化症の個体差および遺伝的影響
  • ウサギ ノ ジッケンテキ ドウミャク コウカショウ ノ コタイサ オヨビ イデ

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Remarkable individual variations were seen in experimentally induced atherosclerosis in male Japanese white rabbits from a closed colony of JW/CSK fed on 1 % cholesterol diet. Correlation analyses revealed that the severity of gross atheromatous lesions was paralleled with aortic cholesterol content and that individual variations in both of these parameters were mainly dependent upon individual variations in the changes of serum cholesterol levels. A genetic effect was suggested as a factor for these variations. Thus, inter-litter differences in aortic cholesterol contents and serum cholesterol levels were highly significant (p<0.01) and it was estimated that inter-litter variances constituted 760 of the inter-individual variances in both parameters. However, an attempt to isolate a pedigree resistant to cholesterol feeding by consanguinity analysis and subsequent mating did not result in success.

Journal

  • EXPERIMENTAL ANIMALS

    EXPERIMENTAL ANIMALS 25 (3), 127-133, 1976

    Japanese Association for Laboratory Animal Science

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