Artificial Nursing of New-born Cynomolgus Monkeys as a Model of the Human Infant and Development of Abnormal Behavior

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  • 乳幼児のモデルとしての仔ザルの人工飼育試験といわゆる隔離サルにおける行動異常
  • ニュウヨウジ ノ モデル トシテノ シ ザル ノ ジンコウ シイク シケン ト

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Description

New-born cynomolgus monkeys were successfully reared by artificial nursing that was started just afterbirth with a 12% solution of a commercially prepared powderedmilk (Yukijirushi, P 7a) containing 13.3g of protein per 100g. Marked growthretardation was observed in baby cynomolgus monkeys fed on a 12% solution of the modified P 7a milk containing only 6.6g of protein per 100g to which lactose was supplemented to give a baby monkey the same caloric value as that of the original P 7a milk. These artificially reared cynomolgus monkeys manifested various kinds of abnormal behavior such as self-clasping, autism-like self mouthing, huddling, stereotype rocking, head-knocking, autoerotism, fear, aggression, etc.. Generally, develop ment of these abnormal behaviors was more noticeable in the monkeys nursed with a milk bottle fixed to the side of a cage without human contact than in the monkeys nursed by a care-taker with bodily touching. These qualitative observational results indicate that the new-born cynomolgus monkey can be used as a model of the human baby for research into the relationship between malnutrition and abnormal physical and mental growth.

Journal

  • EXPERIMENTAL ANIMALS

    EXPERIMENTAL ANIMALS 24 (4), 161-171, 1975

    Japanese Association for Laboratory Animal Science

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