Effects of Heat Treated Cells of Intestinal Lactic Acid Bacteria in Rats Fed a Deoxycholic Acid Diet

DOI Web Site Web Site
  • SHIINA Tsuneko
    <I>Institute for Intestinal and Environmental Microbiology, Advance Co. Ltd.</I>
  • SHIN Ryouichi
    <I>Institute for Intestinal and Environmental Microbiology, Advance Co. Ltd.</I>
  • ISHIHARA Kazuoki
    <I>Institute for Intestinal and Environmental Microbiology, Advance Co. Ltd.</I>
  • ISODA Masae
    <I>Institute for Intestinal and Environmental Microbiology, Advance Co. Ltd.</I>

Bibliographic Information

Other Title
  • デオキシコール酸負荷ラットにおける肝臓および腎臓の障害と腸内乳酸菌加熱処理菌体投与の影響
  • デオキシコールサン フカ ラット ニ オケル カンゾウ オヨビ ジンゾウ ノ

Search this article

Description

Effects of the administration of heat treated cells of intestinal lactic acid bacteria were examined in rats fed a deoxycholic acid (DCA) diet. Male Wistar rats were given a 0.25% DCA diet with or without the heat treated cells of Enterococcus faecalis AD 1001 (EFH-1) or Lactobacillus reuteri AD 0002 (LRH-2) for 4 weeks. Abnormal increases in serum GOT, GPT, UN and lipoproteins were observed in the rats fed the DCA diet. Furthermore, severe lesions in the kidney as well as in the liver were found in these rats. On the contrary, the increases in serum GOT, UN, VLDL and LDL were significantly suppressed, and markedly fewer lesions in the liver and the kidney were observed in the rats fed the DCA diet plus EFH-1 or LRH-2.

Journal

  • Experimental Animals

    Experimental Animals 39 (3), 325-335, 1990

    Japanese Association for Laboratory Animal Science

Details 詳細情報について

Report a problem

Back to top