An Epizootic <I>Staphylococcus</I> Infection in a Nude Mouse Colony

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  • SANO Reiko
    <I>Department of Veterinary Public Health, The Institute of Public Health</I>
  • YAMAMOTO Shigeki
    <I>Department of Veterinary Public Health, The Institute of Public Health</I>
  • KAMIMURA Hiroshi
    <I>Department of Veterinary Public Health, The Institute of Public Health</I>
  • KIMURA Masanobu
    <I>Department of Veterinary Public Health, The Institute of Public Health</I>
  • UEDA Katsumoto
    <I>Department of Veterinary Public Health, The Institute of Public Health</I>
  • SHIMIZU Akira
    <I>Department of Animal Hygiene, Faculty of Agriculture, Kobe University</I>
  • KAWANO Junichi
    <I>Department of Animal Hygiene, Faculty of Agriculture, Kobe University</I>
  • KIMURA Shige
    <I>Department of Animal Hygiene, Faculty of Agriculture, Kobe University</I>

Bibliographic Information

Other Title
  • ヌードマウスコロニーにおけるブドウ球菌感染の流行
  • ヌードマウスコロニーにおけるブドウ球菌感染の流行〔英文〕
  • ヌードマウス コロニー ニ オケル ブドウキュウキン カンセン ノ リュウコウ

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Description

An epizootic of Staphylococcus infection causing abscesses was encountered in a smallscale breeding colony of nude mice of BALB/c background. The incidence of abscess was sporadic and mostly nude (nu/nu) mice aged over 3 months were affected. Staphylococcus aureus was isolated from the face, oral cavity, and feces of almost all nu/nu and heterozygous (nu/+) mice in the colony. After a prolonged time period, up to 10 to 14 months of age, almost all the S. aureus-carrying nu/nu mice produced abscesses and eventually died. Athymicity of the host seemed to be a prerequisite for the abscess formation since nu/+ mice were spared from the lesions. Also, transfer of immunocompetent spleen cells cured the abscesses of the affected nude mice.

Journal

  • Experimental Animals

    Experimental Animals 37 (1), 31-38, 1988

    Japanese Association for Laboratory Animal Science

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