Changes in Movement and Ataxic Gait with Development in Genetically Ataxic Mice: A Comparison with the Level of Cerebellar Cyclic Nucleotide

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  • MATSUI Kyoko
    <I>National Institute of Neuroscience, N. C. N. P.</I>
  • KATO Nobumasa
    <I>Department of Psychiatry, Shiga University of Medical Science</I>
  • ANDO Kazuya
    <I>Division of Neurology, National Chubu Hosptital</I>

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Other Title
  • 遺伝性運動失調マウスの成長発達による行動量・運動失調の変化―小脳cyclic nucleotide濃度との関連において―
  • イデンセイ ウンドウ シッチョウ マウス ノ セイチョウ ハッタツ ニ ヨル

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Description

Spontaneous movement and ataxic gait in ataxic mice showing various pathological changes in the cerebellum were investigated according to developmental stage by the open-field method of comparison with normal mice. As the cerebllum contains relatively high levels of cyclic nucleotide, its concentration was measured by radioimmunoassay to elucidate the correlation between spontaneous movement and ataxic gait and the neurological changes. The movements of Rolling Mouse Nagoya (RMN), Weaver and Reeler mice without Purkinje Cell Degeneration (PCD) were found to decrease at 4 and 12 weeks of age. The degree of ataxic gait worseened in RMN, was unchanged in Reeler and improved in Weaver and PCD mice. The cerebellar c-GMP concentration of ataxic mice was decreased, while no significant changes in c-AMP concentration were found in comparison with normal mice. With development, the level of cerebellar c-GMP in Weaver mice incceased, but this was not apparent in RMN, Reeler or PCD mice. The results of this investigation indicated that there may be some relation between the degree of ataxic gait and the level of cerebellar c-GMP in Weaver mice.

Journal

  • Experimental Animals

    Experimental Animals 37 (1), 1-6, 1988

    Japanese Association for Laboratory Animal Science

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