Measurement of Mean Arteria Pressure in Rats by a Tail-cuff Method with Sensitive Photoelectric Sensors

SAKAMAKI Tetsuo, TAJIMA Yoshihiro, ICHIKAWA Shuichi, MURATA Kazuhiko

doi:10.1538/expanim1978.36.4_409

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Other Title

テールカフ法によるラットの平均血圧測定の信頼性
テールカフ法によるラットの平均血圧測定の信頼性〔英文〕
テールカフホウニヨルラットノヘイキンケツアツソクテイノシンラ

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Description

We evaluated a recently developed tail-cuff apparatus containing sensitive photoelectric sensors in the measurement of arterial pressure in rats. A total of 48 male Wistar rats were used in the study. The indirect mean arterial pressure (MPi) was determined from the cuff pressure when the pulse volume oscillations were maximal. To create sufficiently large pulse volume oscillations, we heated the rats for about 12 minutes at 38°C prior to recording the pressure. The heating increased the mean arterial pressure by an average of 4±2 mmHg, as indicated by direct measurement of pressure. Three different sizes of cuffs were tested, with the result that the indirect measurements were nearly identical to those obtained directly when an appropriate cuff size was selected. The MPi was well correlated with the direct measurement of mean arterial pressure before (r=0.918, p<0.001) and during (r=0.903, p<0.001) elevation of arterial pressure via norepinephrine infusion. These results indicate that the MPi determined at maximum pulse volume oscillations coincides fairly well with the true mean arterial pressure.

Journal

Experimental Animals

Experimental Animals 36 (4), 409-414, 1987

Japanese Association for Laboratory Animal Science

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