Influence of Environmental Temperature on the Mortality of Anaphylactic Shock in Mice

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  • マウスのAnaphylactic shockによる死亡率におよぼす環境温度の影響
  • マウス ノ Anaphylactic shock ニ ヨル シボウリツ ニ オヨボス カンキョウ オンド ノ エイキョウ

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Many reseachers have investigated anaphylactic shock in mice, but there has been no study concerning the effect of the environmental temperature on anaphylactic shock.<BR>In order to investigate the effect of the environmental temperature on the mortality of anaphylactic shock in mice, five strains (ICR-JCL, CF#1-JCL ddN-JCL, C3H/HeN and BALB/c) of mice were used.<BR>The mice were sensitized by subcutaneous injections with 0.08-10mg of egg albumin at five and six weeks of age. These mice were challenged by a subcutaneous injection with 2 mg of egg albumin in a 0.1ml saline solution at seven weeks of age, and thereafter, the mice were divided into three groups and exposed to three different environmental temperatures 10±2°C, 22±1°C or 31±2°C, respectively.<BR>The mortality rate during 70 minutes after challenging is shown in Table 1 and Fig. 1. There was no relation between the sensitized dose and the mortality at each environmental temperature.<BR>The mortalities in each strain increased as the environmental temperature became higher, especially in the C3H/HeN strain, where the mortality at 31°C was 58%, but at 10°C was 0%.<BR>The survival time in ICR-JCL mice after challenging is shown Fig. 2.<BR>The survival time was longer at the lower environmental temperature.

Journal

  • EXPERIMENTAL ANIMALS

    EXPERIMENTAL ANIMALS 17 (1), 7-10, 1968

    Japanese Association for Laboratory Animal Science

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