A cross-sectional study of renal function based on estimated glomerular filtration rate and urinary protein levels related to risk factors for cardiovascular events and metabolic syndrome in local residents

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  • IMAWATARI Ryuichirou
    Kokura medical association health testing and services center Kitakyushu medical association committee on health promotion Kokura medical association in Kitakyushu city Kitakyushu city investigation committee on CKD
  • KAWABE Sakura
    Kitakyushu city investigation committee on CKD Public Health Promotion Division, Regional Support Department, Public Health and Welfare Bureau, City of Kitakyushu
  • TANDA Tomomi
    Kitakyushu city investigation committee on CKD Public Health Promotion Division, Regional Support Department, Public Health and Welfare Bureau, City of Kitakyushu
  • OGAWA Masakatsu
    Kokura medical association health testing and services center Kokura medical association in Kitakyushu city
  • HAMAO Yui
    Kokura medical association health testing and services center Kokura medical association in Kitakyushu city
  • MATSUDA Etsuko
    Kokura medical association health testing and services center Kokura medical association in Kitakyushu city
  • UNO Takuya
    Kokura medical association in Kitakyushu city
  • TANAKA Yutaka
    Kitakyushu medical association committee on health promotion Kitakyushu medical association Kitakyushu city investigation committee on CKD
  • KAGIYAMA Akihiro
    Kitakyushu medical association committee on health promotion Kitakyushu medical association Kitakyushu city investigation committee on CKD
  • OKAMOTO Takaaki
    Kitakyushu medical association Kitakyushu city investigation committee on CKD
  • KANAI Hidetoshi
    Kitakyushu city investigation committee on CKD
  • YANAGIDA Taihei
    Kitakyushu city investigation committee on CKD
  • OUMA Hiroshi
    Kitakyushu medical association

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Other Title
  • 地域住民における推算糸球体濾過量（eGFR）を用いた腎機能と尿蛋白からの心血管疾患リスク要因およびメタボリックシンドロームの断面的検討
  • チイキ ジュウミン ニ オケル スイサン シキュウタイ ロカリョウ(eGFR)オ モチイタ ジンキノウ ト ニョウ タンパク カラ ノ シンケツカン シッカン リスク ヨウイン オヨビ メタボリックシンドローム ノ ダンメンテキ ケントウ

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Abstract

Objectives In a cross-sectional study, we investigated renal function based on estimated glomerular filtration rate (eGFR) and urinary protein levels fromSpecific Health Examinations in Kitakyushu city related to risk factors for cardiovascular events and metabolic syndrome in residents.<br/>Methods For this study, 21,625 citizens (male/female=8,637/12,988) of Kitakyushu city were investigated. Citizens were enrolled in national health insurance and data were collected from a database classified for “Specific Health Guidance” by the Kokura Medical Association health testing and services center in 2010.<br/>Results As a whole, the stage of CKD increased with age, especially among those aged 70–74 years; 32% were at CKD stage 3. Only 11% of the CKD stage 3 group had a positive urinary protein (UP) test. Subjects in stages 3–5 CKD had a higher ratio of abdominal obesity, higher systolic and diastolic blood pressure, increased fasting blood glucose, HbA1c, and fasting triglyceride levels, and lower levels of HDL–C in comparison to subjects with CKD in stages 1–2. These factors increase the complication ratio of MetS for subjects in stages 3–5. The group with a history of stroke or heart disease had a significantly lower eGFR.<br/>Conclusion There is a strong relationship between CKD and risk factors for cardiovascular events and MetS. It has been indicated that lifestyle modifications, suggested by primary care doctors, are very important for the early prevention of CKD. A new preventive CKD system in Kitakyushu city, based on a Specific Health Examination, began during the fiscal year 2011, and this system is expected to decrease the incidence of end-stage renal disease and cardiovascular events.

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