The Different Activation of <I>int</I> Genes in Mammary Carcinomas Developed in Three Mouse Strains Harboring Mouse Mammary Tumor Viruses Derived from DD/Tbr

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  • OKUMOTO Masaaki
    <I>Department of Applied Bioscience, Research Institute for Advanced Science and Technology, University of Osaka Prefecture</I>
  • NISHIKAWA Ryosuke
    <I>Department of Applied Bioscience, Research Institute for Advanced Science and Technology, University of Osaka Prefecture</I>
  • IWAI Mineko
    <I>Department of Applied Bioscience, Research Institute for Advanced Science and Technology, University of Osaka Prefecture</I>
  • IWAI Yoshiaki
    <I>Department of Applied Bioscience, Research Institute for Advanced Science and Technology, University of Osaka Prefecture</I>
  • IMAI Shunsuke
    <I>Department of Pathology, Nara Medical University</I>
  • Mori Nobuko
    <I>Department of Applied Bioscience, Research Institute for Advanced Science and Technology, University of Osaka Prefecture</I>
  • TAKAMORI Yasuhiko
    <I>Department of Veterinary Radiology, University of Osaka Prefecture</I>
  • YAGASAKI Osamu
    <I>Department of Veterinary Phamacology, University of Osaka Prefecture</I>

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Other Title
  • DD/Tbrマウス乳癌ウイルスを保持する3系統のマウスの乳癌における<I>int</I>遺伝子の発現
  • DD/Tbrマウス乳癌ウイルスを保持する3系統のマウスの乳癌におけるint遺伝子の発現〔英文〕
  • DD Tbr マウス ニュウガン ウイルス オ ホジスル 3 ケイトウ ノ マ

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Description

RNA expressions of common integration site (int) genes and several cnogenes were investigated in mammary carcinomas spontaneously developed in different three strains of mice ; DD/Tbr, NIH Swiss and BALB/c which harbor DD-MMTV derived from DD/Tbr mouse. Latter two strains of mice were designated NIH/Mtv+and BALB/Mtv+, respectively. An increased expession ofint-1 (wnt-1) andint-2 genes was observed in 56% (9/16) and 50% (8/16) of mammary carcinomas of DD/Tbr mice, respectively. Eitherint-1 orint-2RNAs were expressed in 81% (13/16) of the carcinomas of DD/Tbr mice. IN NIH/Mtv+mice, activation ofint-1 andint-2 was observed in 41% (7/17) and 24% (4/17) of mammary carcinomas, respectively. Eitherint-1 orint-2 RNAs were expressed in 47% (8/17) of the carcinomas examined in this strain. In BALB/Mtv+mice, on the other hand, eitherint-1 orint-2 genes were transcribed into RNAs at low frequency (33% : 3/9) . These results suggest that the frequency of activation ofintgenes in mammary carcinomas induced by the same DD-MMTV in three strains of mice is genetically defined characteristics of these strains, and that the involvement ofint-1 andint-2 genes in virus-induced mammary carcinogenesis may be influenced by genetic properties of animals. The activation ofint-1 andint-2 genes did not clearly correlate with an increase in the expression of oncogenes examined ; H-ras, K-ras, N-ras, myc, raf, fgr, fms, erbB, mos, andsrcgenes.

Journal

  • Experimental Animals

    Experimental Animals 40 (4), 431-438, 1991

    Japanese Association for Laboratory Animal Science

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