H-2 Haplotype and Sex-related Differences in IgG Response to Ovalbumin in Mice

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  • TAKEYOSHI Masahiro
    <I>Hita Research Laboratories, Chemicals, Inspection and Testing Institute</I> <I>The United Graduate School of Veterinary Sciences, Yamaguchi University</I>
  • INOUE Takeshi
    <I>The United Graduate School of Veterinary Sciences, Yamaguchi University</I>

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Other Title
  • H-2 haplotypeおよび性差にともなうマウスの卵白アルブミンに対するIgG応答の相違
  • H-2 haplotypeおよび性差にともなうマウスの卵白アルブミンに対するIgG応答の相違〔英文〕
  • H-2 haplotype オヨビ セイサ ニ トモナウ マウス ノ ランパク

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Abstract

Specific IgG antibodies were determined by enzyme-linked immunosorbent assay (ELISA) in 7 strains of male and female mice after immunization with ovalbumin. Also, H-2 haplotype and sex-related differences in IgG response to ovalbumin were evaluated using statistical methods, slope ratio assay and parallel line assay. H-2kstrain mice (C3H/HeN and CBA/JN) showed higher IgG responsiveness to ovalbumin than H-2d (BALB/cAnN and DBA/2 N) and H-2b (C57BL/6 N) mice. With regard to the sex-related differences in IgG response to ovalbumin, females in some strains showed higher IgG response than males, but some strains showed no sex-related differences, and sex-related differences in IgG response to ovalbumin did not relate to their H-2 haplotypes. These results may be caused by other immune response genes which control the sex-related immune response than H-2 or other unknown factors.

Journal

  • Experimental Animals

    Experimental Animals 41 (3), 315-319, 1992

    Japanese Association for Laboratory Animal Science

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