Finding Clear Cell Ependymoma

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  • Clear Cell Ependymomaの発見
  • Clear Cell Ependymoma ノ ハッケン

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The first case of clear cell ependymoma is introduced with the episodes how the author struggled and managed to reach a right diagnosis of the tumor. In 1982, a 22 years old man was revealed to have a calcified tumor with ring enhancement by CT scan within the right frontal lobe. At operation, the tumor was well demarcated from the surrounding brain tissue as if it had a capsule and it adhered to the wall of lateral ventricle. Histologically, as the major part of the tumor tissue was composed of clear round tumor cells with chicken wire appearance, a diagnosis of oligodendroglioma was given by the pathology department. On the other hand, the author recognized that the tumor cells had fine processes and formed epithelial lining in a limited area. GFAP (glial fibrillary acidic protein) immunostaining and electron microscopy were performed and they showed that all the tumor cells were neoplastic ependymal cells, namely it was ependymoma entirely. As this histological pattern of ependymoma has not been recognized in the past, the case was reported as a " Clear Cell Variant of Ependymoma " in 1983, and later its name was changed to " Clear Cell Ependymoma " in 1989. The author wishes to thank several doctors who offered invaluable advices in the study of this case. They are late Dr. Y. Nishiyama, Dr. Saburo Yagishita, late Dr. E. Alvord, and Dr. D. Horoupian.

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