Effect of α-lactoalbumin on the frequent urination induced by cyclophosphamide in rats

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  • シクロフォスファミド惹起ラット出血性膀胱炎による頻尿に対するα-ラクトアルブミンの作用
  • シクロフォスファミド ジャッキ ラット シュッケツセイ ボウコウエン ニ ヨル ヒンニョウ ニ タイスル a-ラクトアルブミン ノ サヨウ

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<p>　Frequent urination is a serious problem and remarkably decrease the Quality of Life. However, frequent urination has been also reported as an adverse effect in anti-cancer drugs therapy using cyclophosphamide and ifosfamide. Then, the present study aimed to investigate the effect of α-lactoalbumin on the frequent urination induced by cyclophosphamide in Sprague-Dawley strain female rats. Cyclophosphamide dissolved in saline was administered intraperitoneally at doses of 50 and 150 mg/kg. Distilled water for injection was administered orally in a volume of 20 ml/kg after 2 days of cyclophosphamide-treatment. Thereafter, urination number of times and urine volume were measured every 15 min till 120 min. At a dosage of 150 mg/kg, significant increase of urination number of times and significant decrease of the average urination volume were observed, but not at 50 mg/kg. Then, the effect of α-lactoalbumin was evaluated by the administration of 150 mg/kg of cyclophosphamide. α-Lactoalbumin and dexamathason were administered orally at a dosage of 1000 and 5 mg/kg, respectively, before and after cyclophosphamide administration. Urination test was performed 2 days after cyclophosphamide. α-Lactoalbumin and dexamathason markedly decreased the urination number of times, and at 120 min α-lactoalbumin showed a significant decrease (p<0.05). Moreover, α-lactoalbumin significantly attenuated the significant decrease of the average urination volume induced by cyclophosphamide. Dexamathason also showed almost the same efficacy as α-lactoalbumin. These results show that α-lactoalbumin is effective on the frequent urination induced by cyclophosphamide.</p>

Journal

  • Milk Science

    Milk Science 66 (3), 189-194, 2017

    Japanese Dairy Science Association

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