Prospect of hepatocyte transplantation based on the experience of treating infantile urea cycle disorder

DOI
  • Shigeta Takanobu
    Transplantation Center National Center for Child Health and Development
  • Enosawa Shin
    Advanced Medical Sciences National Center for Child Health and Development
  • Matsunami Masatoshi
    Transplantation Center National Center for Child Health and Development
  • Sasaki Kengo
    Transplantation Center National Center for Child Health and Development
  • Uchida Hajime
    Transplantation Center National Center for Child Health and Development
  • Kanazawa Hiroyuki
    Transplantation Center National Center for Child Health and Development
  • Fukuda Akinari
    Transplantation Center National Center for Child Health and Development
  • Horikawa Reiko
    Endocrinology National Center for Child Health and Development
  • Nosaka Shunsuke
    Radiology National Center for Child Health and Development
  • Kasahara Mureo
    Transplantation Center National Center for Child Health and Development

Bibliographic Information

Other Title
  • 肝細胞移植の展望　̶新生児期発症の尿素サイクル異常への移植経験から　̶

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Abstract

Hepatocyte transplantation (HT) is attractive option for urea cycle disorder and acute liver failure. HT has the benefit of non-invasive treatment, availability of hepatocyte isolated from marginal donors and cryopreserved hepatocytes at the time of need. On the other hand, the disadvantages of HT are injury of hepatocytes after thawing, difficulty of monitoring acute cellular rejection after HT, and limited donor source for HT. We experienced HT for neonatal ornithine transcarbamylase deficiency patient using hepatocytes from living donor for the fi rst case in the world. In our study, hepatocytes were isolated from the redundant liver of reduced left lateral segment graft from living donor. The quality of hepatocytes from living donor is better than that from deceased donor. The patient underwent living donor liver transplantation from his mother 5 months after HT.

Journal

  • Organ Biology

    Organ Biology 22 (2), 171-175, 2015

    The Japan Society for Organ Preservation and Biology

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