再生医療用同種iPS 細胞ストックのドナーリクルートについて

DOI
  • 齋藤 潤
    京都大学iPS 細胞研究所・臨床応用研究部門

書誌事項

タイトル別名
  • Donor recruitment of allogeneic iPS cell repository for regenerative medicine

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説明

Human induced pluripotent stem cells (iPSCs) are pluripotent cell lines that can be established from somatic cells of any donor. Human iPSC-based cell/tissue transplantation has been regarded as one of their most attractive application. Although autologous iPSC-based cell therapy is preferable to avoid graft rejection, it would be fi nancially prohibitive to generate iPSCs for each individual. Therefore, it is necessary to consider allogeneic transplantation from human leukocyte antigen (HLA) -matched donors. In Japan, we have aimed to establish multiple clinical grade iPSC lines from donors that are homozygous for three HLA loci: HLA-A, -B and -DR, in order to establish an iPSC bank for medical use. Here I focus on the donor eligibility criteria and contents of the informed consent for the clinical iPS cell bank project in Japan.

収録刊行物

  • Organ Biology

    Organ Biology 22 (2), 136-141, 2015

    一般社団法人　日本臓器保存生物医学会

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