Effectiveness of triangular and saw-tooth pulses in a retinal prosthesis with suprachoroidal-transretinal stimulation (STS)

DOI
  • Nakano Yukari
    Artificial Vision Institute, Research and Development Division, Nidek Co., Ltd.
  • Terasawa Yasuo
    Artificial Vision Institute, Research and Development Division, Nidek Co., Ltd. Graduate School of Materials Science, Nara Institute of Science & Technology
  • Kanda Hiroyuki
    Department of Applied Visual Science, Osaka University Graduate School of Medicine
  • Osawa Kouji
    Artificial Retina Development Office, Development Division, Nidek Co., Ltd.
  • Miyoshi Tomomitsu
    Department of Integrative Physiology, Osaka University Graduate School of Medicine
  • Sawai Hajime
    Department of Health Sciences, School of Nursing, Osaka Prefecture University
  • Fujikado Takashi
    Department of Applied Visual Science, Osaka University Graduate School of Medicine

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  • 脈絡膜上-経網膜刺激方式人工視覚における三角波と鋸波電流パルスの有効性

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Abstract

<p>Retinal prostheses electrically stimulate retinas with photoreceptor cell degeneration to evoke a pseudo light sensation (phosphenes). Rectangular pulse electrical stimulation is generally used for retinal prosthesis. In this study, we attempted to determine more effective electrical stimulation parameters by electrophysiologically examining the stimulation efficiency of four stimulation waveform shapes (rectangular, triangular, saw-tooth, and inverse saw-tooth). A stimulation electrode and a return electrode were set on one eyeball of each rat, and a single biphasic, cathodic-first current pulse was applied between the electrodes. The four types of waveforms of equal charge quantity were then compared. Significantly larger neural response amplitudes were observed for the triangular and saw-tooth pulses than for the rectangular pulse, suggesting that electrical stimulation could be applied with a lower electric charge using a triangular and saw-tooth pulses.</p>

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