Possible resource for human hepatocytes: remnant liver of hyper-reduced left lateral segment graft in living donor liver transplantation

DOI
  • Shigeta Takanobu
    Organ Transplantation Center, National Center for Child Health and Development
  • Enosawa Shin
    Division for Advanced Medical Sciences, National Center for Child Health and Development
  • Kanazawa Hiroyuki
    Organ Transplantation Center, National Center for Child Health and Development
  • Fukuda Akinari
    Organ Transplantation Center, National Center for Child Health and Development
  • Sakamoto Seisuke
    Organ Transplantation Center, National Center for Child Health and Development
  • Kasahara Mureo
    Organ Transplantation Center, National Center for Child Health and Development

Bibliographic Information

Other Title
  • 超減量外側区域グラフト採取時の余剰肝を用いた細胞分離

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Abstract

Hepatocyte transplantation (HCT) is a promising option for the non-invasive treatment of acute liver failure and urea cycle disorder. A problem to solve in HCT is the limited availability of cell donor. Here, we review the possibility of use of remnant liver of hyper reduced left lateral segment(HRLLS)graft from living donor liver transplantation as the cell source. Because liver transplantation for low body weight infants often needs reduction of an adult liver of which quality is assured to be compatible to transplantation. Thus, the remnant liver tissues provide the best opportunity of hepatocytes banking. In Japan, the research use of organs from brain dead donor is not allowed legally and the remnant liver of HRLLS graft of living donor is only invaluable resource. Indeed, the quality of cells isolated by ourselves showed comparable to that reported by oversea researchers. We propose that the remnant liver of HRLLS graft from living donor could be an important cell source for HCT.

Journal

  • Organ Biology

    Organ Biology 21 (2), 212-214, 2014

    The Japan Society for Organ Preservation and Biology

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