Development of a novel organ perfusion culture system to expand donor organs

DOI
  • Ishikawa Jun
    Laboratory for Organ Regeneration, RIKEN Center for Developmental Biology
  • Yoshimoto Shuhei
    Laboratory for Organ Regeneration, RIKEN Center for Developmental Biology SCREEN holdings Inc
  • Torai Shinji
    Laboratory for Organ Regeneration, RIKEN Center for Developmental Biology SCREEN holdings Inc
  • Kobayashi Eiji
    Laboratory for Organ Regeneration, RIKEN Center for Developmental Biology Department of Organ Fabrication, Keio University, School of Medicine
  • Tsuji Takashi
    Laboratory for Organ Regeneration, RIKEN Center for Developmental Biology SCREEN holdings Inc Organ Technologies Inc

Bibliographic Information

Other Title
  • ドナー臓器の利用拡大に向けた臓器保存・蘇生技術の開発

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Description

Organ transplantation is currently used to replace a dysfunctional organ and to restore organ function in vivo. This therapy is widely spread and recognized as radical treatment for patients unlikely to heal with medical treatment. Although this method has been developed, there is a worldwide donor organ shortage that remains an unresolved problem. To resolve the problem, the ways of donor organ preservation are developed and also studied the using marginal donors. However, these approaches have not yet solved the problem because of donor organs maintain healthy conditions only during short-term storage or decline the survival late. In this study, we developed a novel liver perfusion culture system based on biological physical functions that can not only preserve the donor organ for long term but also allows for the resurrection of a severely ischaemic liver. This study represents a significant advance for the development of an ex vivo organ perfusion system. It can be used not only to address donor organ shortages but also as the basis of future regenerative organ replacement therapy.

Journal

  • Organ Biology

    Organ Biology 24 (1), 21-28, 2017

    The Japan Society for Organ Preservation and Biology

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