Role of Pannexin 3, a Gap Junction Protein, in Cartilage Development

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  • IWAMOTO Tsutomu
    Division of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry

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  • 軟骨形成過程におけるギャップ結合分子パネキシン3の役割

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Abstract

Cartilage formation with subsequent skeletal formation in childhood is very important for growth and development of children. Most bones develop by endochondral ossification, a process to replace a template of hyaline cartilage with bone. Endochondral ossification including cartilage resorption and bone formation requires a carefully orchestrated interplay of three major cell types : chondrocytes,osteoclasts and osteoblasts. Recent advances in molecular biological techniques have provided insight into the differentiation mechanisms of those cells.Pannexin 3, a gap junction protein, was found in cartilage cDNA by bioinformatical analysis. Pannexin 3 is expressed by prehypertrophic chondrocyte in growth plate, and regulates chondrocyte proliferation and differentiation by ATP hemichannel.Here this paper describes the process of endochondral ossification and discuss the role of pannexin 3 in cartilage development.

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