Peking University - Juntendo University Joint Symposium on Brain and Skin Diseases

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  • TENG ZE
    Peking University Third Hospital, Beijing Key Laboratory of Magnetic Resonance Imaging Devices and Technology
  • LIU BIN
    Department of Interventional Medicine, The Second Hospital of Shandong University, Interventional Oncology of Shandong University
  • LI YULIANG
    Department of Interventional Medicine, The Second Hospital of Shandong University, Interventional Oncology of Shandong University
  • HAN HONGBIN
    Peking University Third Hospital, Beijing Key Laboratory of Magnetic Resonance Imaging Devices and Technology

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  • Measurement of the Brain Extracellular Space Using Tracer-Based MRI

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<p>Neurons have been considered the most important functional unit of the brain and have attracted the most attention in neurobiology. Neural cells occupy 70%-80% of the whole brain volume, but until now, our current knowledge of neural circuit cannot explain all the neurological conditions of the brain. Thus, it is also important to consider the influence of the extracellular space (ECS) around neural cells, which contains the brain interstitial fluid (ISF). This paper includes the anatomy of the brain ECS under physiological condition, the in vivo measurement techniques of brain ECS, and the divisions of brain ECS. Moreover, the implications of ECS knowledge of basic neuroscience and clinical applications are introduced, including the brain tissue engineering and the local drug delivery via ECS. </p>

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