Current Treatment Options for Inflammatory Bowel Diseases and Future Perspectives
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- OSADA TARO
- Department of Gastroenterology, Juntendo University Faculty of Medicine
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- WATANABE SUMIO
- Department of Gastroenterology, Juntendo University Faculty of Medicine
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説明
In recent years, landmark progress has been made in the treatment of patients with inflammatory bowel diseases (IBD). The anti-tumour necrosis factor (TNF) -α antibody era has shown that mucosal healing is a key therapeutic goal, and may predict the sustainability of remission or resection-free survival in IBD patients. Further, the anti-TNF-α antibody infliximab (IFX) became an alternative medication for refractory UC in 2010 under the Japan national health reimbursement scheme. However, to induce remission in steroid-refractory UC, currently several therapeutic options are available in Japan including cytapheresis, tacrolimus, and anti-TNF-α biologics, but as yet, there are no guidelines for the sequence and timing of these therapeutic interventions. Additionally, there are many patients who do not respond, or are intolerant, to anti-TNF-α biologics. Recently, new strategies like faecal microbiota transplantation and anti-leucocyte infiltration have been tested for induction and maintenance of remission in IBD patients. This paper provides an overview of the latest treatment options and future perspectives in IBD therapy.
収録刊行物
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- 順天堂醫事雑誌
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順天堂醫事雑誌 61 (6), 588-596, 2015
順天堂医学会
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詳細情報 詳細情報について
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- CRID
- 1390282680495388544
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- NII論文ID
- 130005133290
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- NII書誌ID
- AA1262207X
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- ISSN
- 21882126
- 21879737
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- NDL書誌ID
- 027165366
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可