Expression changes of glial cell line-derived neurotrophic factor in a rat model of neuropathic pain
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- Takahashi Naoki
- Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University
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- Nagano Masatoshi
- Department of Pharmacology, Nippon Medical School
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- Suzuki Hidenori
- Department of Pharmacology, Nippon Medical School
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- Umino Masahiro
- Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University
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説明
To reveal roles of neurotrophic factors in plastic changes of the primary afferent neurons following nerve injury, we investigated expression of glial cell line-derived neurotrophic factor (GDNF) as well as nerve growth factor (NGF) in a neuropathic pain model of the rat. The rats exhibited hyperalgesia and allodynia on the injured left side for at least 2 weeks after chronic constrictive injury to the sciatic nerve. Accompanied by the behavioral changes, expression of GDNF decreased in the dorsal root ganglia (DRGs) and the sciatic nerve on the injured side on the fourteenth day after the surgery. In contrast, the amount of NGF in DRGs was unchanged in spite of disturbance of NGF transport in the nerve. The present results suggest that decreased expression of GDNF takes some part in development and/or maintenance of neuropathic pain.
収録刊行物
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- Journal of Medical and Dental Sciences
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Journal of Medical and Dental Sciences 50 (1), 87-92, 2003
国立大学法人 東京医科歯科大学
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詳細情報 詳細情報について
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- CRID
- 1390282680495882880
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- NII論文ID
- 110000076022
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- NII書誌ID
- AA12028964
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- ISSN
- 21859132
- 13428810
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可