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Effect of Neurotropin on Chronic Headaches in Children
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- Saito Yoshiaki
- Department of Child Neurology, National Center of Neurology and Psychiatry
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- Fukumura Shinobu
- Department of Child Neurology, National Center of Neurology and Psychiatry
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- Saito Takashi
- Department of Child Neurology, National Center of Neurology and Psychiatry
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- Komaki Hirofumi
- Department of Child Neurology, National Center of Neurology and Psychiatry
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- Nakagawa Eiji
- Department of Child Neurology, National Center of Neurology and Psychiatry
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- Sugai Kenji
- Department of Child Neurology, National Center of Neurology and Psychiatry
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- Sasaki Masayuki
- Department of Child Neurology, National Center of Neurology and Psychiatry
Bibliographic Information
- Other Title
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- Neurotropinが奏効した小児難治性慢性頭痛の2例
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Description
We report the cases of 2 girls, aged 13 and 15 years, who experienced exacerbation of migraine at 2-3 years after its onset. The chronic headaches were refractory to various anti-migraine and analgesic agents, persisted for 3-6 months in each patient, and rendered them unable to attend school. These headaches commonly manifested with symptoms of orthostatic dysregulation and paroxysmal back/limb pain. In addition, T2-weighted magnetic resonance images showed dots of highly intense signals in the bilateral cerebral white matter. Neurotropin, a non-protein extract isolated from the dermis of rabbits and inoculated with the vaccinia virus, induced prompt significant effects on the headache and back/limbs pain in both the girls. The symptom of orthostatic dysregulation was also gradually ameliorated after the resolution of the headache. Neurotropin has an analgesic action that is not common to other drugs since it enhances the descending pain inhibitory systems, and its effect has been reported in cases of post-herpetic and other neuralgia as well as in cases of primary headaches in adulthood. This agent may also be promising for the treatment of intractable primary headaches during childhood.
Journal
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- NO TO HATTATSU
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NO TO HATTATSU 44 (6), 477-481, 2012
The Japanese Society of Child Neurology
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Details 詳細情報について
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- CRID
- 1390282680495982848
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- NII Article ID
- 10031122024
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- NII Book ID
- AN0020232X
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- ISSN
- 18847668
- 00290831
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed
