INTERACTION BETWEEN QUERCETIN AND Ca<sup>2+</sup>-CALMODULIN COMPLEX
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- NISHINO Hoyoku
- Department of Biochemistry, Kyoto Prefectural University of Medicine
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- NAITO Eiji
- Department of Biochemistry, Kyoto Prefectural University of Medicine
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- IWASHIMA Akio
- Department of Biochemistry, Kyoto Prefectural University of Medicine
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- TANAKA Ken-ichi
- Kyoto Red Cross Blood Center
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- MATSUURA Takao
- Kyoto Red Cross Blood Center
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- FUJIKI Hirota
- National Cancer Center Research Institute
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- SUGIMURA Takashi
- National Cancer Center Research Institute
Bibliographic Information
- Other Title
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- POSSIBLE MECHANISM FOR ANTI-TUMOR-PROMOTING ACTION OF THE FLAVONOID
Abstract
Quercetin was found to have similar inhibitory effects on tumor promoter-induced phenomena to those of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist. Moreover, quercetin was shown to interact directly with the Ca2+-calmodulin complex. These results suggest that quercetin may act as a calmodulin antagonist, and that its antagonistic effect on calmodulin may be important in its anti-tumor-promoting action in vivo.
Journal
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- GANN Japanese Journal of Cancer Research
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GANN Japanese Journal of Cancer Research 75 (4), 311-316, 1984
The Japanese Cancer Association
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Details 詳細情報について
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- CRID
- 1390282680503548800
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- NII Article ID
- 130006408182
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- ISSN
- 0016450X
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- Text Lang
- en
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed
