KINETICS OF TUMOR CELL DEATH BY HYPERTHERMIC TREATMENT AND X-RAY IRRADIATION

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  • OKUMURA Yutaka
    Department of Radiation Biophysics, Atomic Disease Institute, Nagasaki University School of Medicine

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  • Kinetics of Tumor Cell Death by Hyperth

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Abstract

Kinetics of cell death by hyperthermic treatment at 44° was analyzed using cultured mouse mammary carcinoma cells, and compared with that after X-irradiation. The cells treated with hyperthermia began to die randomly with a mean lethal time of 10hr after a lag time of 10hr. After irradiation, the lag time and mean lethal time were 40 and 34hr, respectively. Early appearance of dead cells by hyperthermic treatment indicates that the critical target is related to cellular metabolism.

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