CHEMOTHERAPY OF INDUCED SKIN TUMORS IN MICE

杉浦 兼松

doi:10.20772/cancersci1959.59.5_367

CHEMOTHERAPY OF INDUCED SKIN TUMORS IN MICE

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杉浦兼松

Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research

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Twenty selected compounds were tested for antitumor activity against DMBA-induced skin tumors in mice.<br>Cytoxan and 6-mercaptopurine were the most effective, producing complete regression of papillomas in 57%, in contrast to 28% spontaneous regression in the controls. Cytoxan also caused complete destruction of squamous cell carcinomas in 25% while none occurred in the controls.<br>Repeated subcutaneous injections of testosterone propionate definitely increased the frequency of regressions of DMBA-induced papillomas in female mice (56%) while the same tumors were resistant (9%) to estradiol, a female sex hormone. Testosterone propionate caused complete destruction of squamous cell carcinoma in 40% of the cases, while estradiol was ineffective against squamous cell carcinoma.