INHIBITION OF FUNCTIONAL AND MORPHOLOGICAL DIFFERENTIATION OF CULTURED MOUSE MYELOID LEUKEMIA CELLS BY TUMOR PROMOTERS

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  • Inhibition of Functional and Morphologi

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Addition of a potent tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA), to mouse myeloid leukemia line cells (M1) in suspension cultures inhibited both functional and morphological differentiation of the cells induced by dexamethasone or protein inducer. A positive correlation was found between the tumor-promoting activities of several plant diterpenes and their inhibition of cell differentiation. The inhibition of cell differentiation by TPA was reversible and was unrelated to its cytotoxic action.

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