EFFECT OF <i>NOCARDIA RUBRA</i> CELL-WALL SKELETON ON THE INDUCTION OF LUNG CANCER IN ACI/N RATS

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  • NAMBA Manabu
    Third Department of Internal Medicine, Osaka University Medical School
  • YOSHIMOTO Takahiko
    Third Department of Internal Medicine, Osaka University Medical School
  • OGURA Takeshi
    Third Department of Internal Medicine, Osaka University Medical School
  • HIRAO Fumio
    Third Department of Internal Medicine, Osaka University Medical School
  • AZUMA Ichiro
    Third Department of Internal Medicine, Osaka University Medical School
  • YAMAMURA Yuichi
    Third Department of Internal Medicine, Osaka University Medical School

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Other Title
  • Effect of Nocardia Rubra Cell-Wall Skeleton on the Induction of Lung Cancer in Aci/n Rats
  • Effect of Nocardia Rubra Cell Wall Skel

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Abstract

Administration of oil-attached Nocardia rubra cell-wall skeleton (N. rubra-CWS) was evaluated for the effect on the induction of lung cancers in ACI/N rats. Lung cancers were induced by 15 weekly intratracheal instillations of 3mg benzo [a]-pyrene with 3mg ferric oxide. After the 10th instillation of the carcinogen, rats received seven subcutaneous injections of 100μg of N. rubra-CWS at 2-week intervals. In the observation period of 56 weeks, the cumulative incidence of lung cancer was 71.4% in the control group and 48.0% in the N. rubra-CWS treated group. The latent period of tumor induction was prolonged in the group treated with N. rubra-CWS.

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