EXPERIMENTAL CHEMOTHERAPY OF CARCINOMA OF THE HUMAN STOMACH AND COLON SERIALLY TRANSPLANTED IN NUDE MICE
書誌事項
- タイトル別名
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- Experimental Chemotherapy of Carcinoma
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抄録
Human gastric and colon carcinomas serially transplantable in nude mice, designated as St-4, St-15, and Co-3, were used for chemotherapeutic experiments. All tumors showed a 100% take rate and stable growth.<br>Mitomycin-C (MMC), 3mg/kg body weight, given intraperitoneally 4 times once weekly, showed some inhibiting effect on Co-3, St-15, and St-4 in that order. N1-(2'-Tetrahydrofuryl)-5-fluorouracil (FT-207), 90mg/kg body weight, intraperitoneally daily for 4 weeks, suppressed the growth of Co-3 and St-15 slightly but with statistical significance, and had no effect on St-4. Co-3, a tumor with more rapid growth and richer vascular supply, was suppressed more by MMC and FT-207.<br>These three transplantable tumors may be useful, not only in evaluating chemotherapeutic agents for use against human gastrointestinal carcinomas, but also for screening of new antitumor agents.
収録刊行物
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- GANN Japanese Journal of Cancer Research
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GANN Japanese Journal of Cancer Research 69 (3), 299-309, 1978
日本癌学会
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詳細情報 詳細情報について
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- CRID
- 1390282680507199488
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- NII論文ID
- 130006409731
- 40000528912
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- NII書誌ID
- AN00045888
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- NDL書誌ID
- 1946360
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- ISSN
- 0016450X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可