CARCINOGENICITY OF TAR-CONTAINING SKIN DRUGS
書誌事項
- タイトル別名
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- ANIMAL EXPERIMENT AND CHEMICAL ANALYSIS
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説明
The carcinogenicity of tar-containing skin drugs, Pityrol, Glyteer, Ichthammol JP. pine tar JP, and Metashal, was investigated by animal experiments and by chemical analysis of carcinogenic aromatic hydrocarbons. The results of animal experiments showed that the proportions of skin papilloma-bearing mice as compared to those at the first appearance of tumor were 64% (Pityrol), 71% (Glyteer), 9% (Ichthammol), 23% (pine tar), and 64% (Metashal). The proportions of skin carcinoma-bearing mice were 36% (Pityrol), 40% (Glyteer), 0% (Ichthammol), 6% (pine tar), and 22% (Metashal). A high proportion (37%) of metastasis in adjacent or remote organs was observed. No tumors developed in the control group that received acetone only.<br>As for chemical analysis, a substantial amount of polycyclic aromatic hydrocarbons and, in particular, of benzo[a]pyrene was identified. The content of benzo[a]-pyrene agreed well with the degree of carcinogenic activity observed by the animal experiment. The average amount of benzo[a]pyrene, from three measurements, were 145 (Pityrol), 129 (Glyteer), none (Ichthammol), 48 (pine tar), and 80μg/10g (Metashal).<br>The carcinogenicity of these drugs in man is difficult to assess at present and further epidemiologic studies appear to be needed to clarify this point.
収録刊行物
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- GANN Japanese Journal of Cancer Research
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GANN Japanese Journal of Cancer Research 64 (4), 323-330_2, 1973
日本癌学会
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詳細情報 詳細情報について
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- CRID
- 1390282680507517312
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- NII論文ID
- 130006409193
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- ISSN
- 0016450X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
