ULTRASTRUCTURAL FINDINGS OF ADENOVIRUS TYPE 12-INDUCED TUMOR CELLS TREATED BY DIFFERENTIAL HYPOTHERMIA
説明
The effect of differential hypothermia, to keep tumor normothermic and general body hypothermic, on the cheek-pouch tumor of a Syrian hamster was investigated by an electron microscope.<br>In the tumor cells, condensation of nuclear chromatin, cystic dilatation of perinuclear cisternae, swelling of mitochondria, and disappearance of mitochondrial cristae were observed immediately after a 10-hr differential hypothermia. Vacuolization in the nucleus of some tumor cells was observed 12hr after the treatment, while the fibrocytes or fibroblasts in the submucosa of the cheek-pouch preserved their normal appearance almost wholly even 12hr after the treatment. On the other hand, aggregated intracisternal C-type virus particles of about 100nm in diameter were observed 12hr after the treatment.<br>Although the destruction of the nuclei of tumor cells became conspicuous, the membrane of some mitochondria still preserved its normal appearance even 24hr after the treatment.
収録刊行物
-
- GANN Japanese Journal of Cancer Research
-
GANN Japanese Journal of Cancer Research 63 (6), 725-730_4, 1972
日本癌学会
