COMBINED EFFECT OF X-RAY AND BLEOMYCIN ON CULTURED MAMMALIAN CELLS

DOI PubMed
  • TERASIMA Toyozo
    Division of Physiology and Pathology, National Institute of Radiological Sciences
  • TAKABE Yosinobu
    First Department of Medicine, Chiba University School of Medicine
  • YASUKAWA Mieko
    Division of Physiology and Pathology, National Institute of Radiological Sciences

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Description

Investigations were carried out with cultured mammalian cell lines to assess the effect of combination of radiation and Bleomycin. When cells were treated with the antibiotic before and during exposure to X-rays, a slight potentiating effect was consistently found. The magnitude of potentiation of the radiation effect appeared to depend on the concentration of Bleomycin. When the cells were treated pulsewise at various periods after irradiation, the potentiating effect was found only during the first 2hr. Simultaneous application of X-rays and Bleomycin provided the greatest effect.

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Details 詳細情報について

  • CRID
    1390282680508552960
  • NII Article ID
    130006409441
  • DOI
    10.20772/cancersci1959.66.6_701
  • ISSN
    0016450X
  • PubMed
    57892
  • Text Lang
    en
  • Data Source
    • JaLC
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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