GROWTH BEHAVIOR OF SPONTANEOUS HEPATOMA IN C3HO MICE

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Biological studies are reported on spontaneous hepatoma occurring in C3HO and ddO mice. Incidence of such hepatomas in male mice was higher than that in female mice, and castrated male mice had median rate between them. The size of hepatoma cells varied between that of normal liver cells and one-half the normal size.<br>This tumor was histologically benign but there was at least one case of pulmonary metastasis. To know their biological character the growth rate of hepatomas was studied in several ways; actual measurement of the diameter of individual hepatoma in two different age groups (4 to 16 weeks), ratio of the hepatoma cells to endothelial cells, use of the mitotic index in histological sections, and use of the labeling index in autoradiography.<br>From the data obtained in autoradiography, the expected life cycle of hepatoma cells was calculated and compared with that of other tissue cells. It was concluded that spontaneous hepatoma in mice has one of characters of malignancy, a capacity to grow with a slow rate.

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