From genome and epigenome to nucleome: Towards to comprehensively understanding gene regulation mechanism

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  • KIMURA Hiroshi
    Tokyo Institute of Technology, Institute of Innovative Research, Cell Biology Center
  • SATO Yuko
    Tokyo Institute of Technology, Institute of Innovative Research, Cell Biology Center

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  • ゲノム，エピゲノムからヌクレオームへ：遺伝情報発現制御機構の包括的理解に向けて
  • ゲノム,エピゲノム カラ ヌクレオーム エ : イデン ジョウホウ ハツゲン セイギョ キコウ ノ ホウカツテキ リカイ ニ ムケテ

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<p>The genetic information of a living organism is encoded on the genomic DNA. To fully understand the phenomenon of life, it is critical to elucidate how genes are expressed as required. In addition to the regulation by transcription factors that bind to specific DNA sequence, epigenetic histone medications and chromatin conformation in the nucleus are also crucial. Recently, "Nucleome" research has been highlighted, as the gene regulation can only be addressed in the context of cell nucleus in space and time. From the aspect of "Nucleome", integrated analyses of microscopy, genome biology, and informatics and mathematical sciences would be facilitated. The 4D Nucleome Program has already been funded in the US, and the 4D Nucleome Initiative in Europe has launched. There is a movement of launching "The International Nucleome Consortium". "Nucleome" research should be facilitated also in Japan.</p>

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