Novel regulation of COP9 Signalosome (CSN): a master regulator of signal transduction in plant morphogenesis

DOI

Bibliographic Information

Other Title
  • 環境情報とかたち作りとを結ぶCOP9シグナロソームの新規制御メカニズムの解析

Abstract

In Arabidopsis, ten COP/DET/FUS genes were genetically identified as negative regulators of photomorphogenesis. Six of these genes code proteins which form a nuclear protein complex called the COP9 Signalosome (CSN). CSN has been shown to modulate signal transduction pathways involved in cell cycle, morphogenesis, and stress response, through its regulation on the ubiquitin-proteasome degradation pathway. <br>Functional dissection in animal cells revealed that the N-terminal portion of CSN1 (CSN1N) represses the SAPK/JNK1 signaling pathway by transcriptional repression. CSN1N also reduces accumulation of JNK1 protein, leading to suppression of c-Jun phosphorylation. To analyze this regulation of CSN1, we have isolated a novel spectrum of proteins (NBPs) that directly bind to CSN1N, such as components of transcription/RNA processing complexes. <br>We are currently analyzing the Arabidopsis NBP orthologs and its knockout plants. Detailed biochemical analyses on the CSN-NBP interactions together with in planta research will reveal the novel mechanism of CSN on signal transduction.

Journal

Details 詳細情報について

  • CRID
    1390282680604835328
  • NII Article ID
    130006988430
  • DOI
    10.14841/jspp.2005.0.870.0
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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