Novel FT-ICR/MS Metabolomics Approach with the van Krevelen Diagram
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- Kai Kosuke
- Research Association for Biotechnology Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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- Kitano Shinya
- Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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- Yasuda Shuhei
- Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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- Takahashi Hiroki
- Graduate School of Information Science, Nara Institute of Science and Technology
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- Shojo Masayuki
- Graduate School of Information Science, Nara Institute of Science and Technology
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- Sakurai Nozomu
- Kazusa DNA Research Institute
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- Suzuki Hideyuki
- Kazusa DNA Research Institute
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- Shibata Daisuke
- Kazusa DNA Research Institute
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- Kanaya Shigehiko
- Graduate School of Information Science, Nara Institute of Science and Technology
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- Ohta Daisaku
- Graduate School of Life and Environmental Sciences, Osaka Prefecture University
Bibliographic Information
- Other Title
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- van Krevelen diagram を用いた新規メタボローム解析ツールの開発
Abstract
Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR/MS) is characterized by its extremely high resolution, allowing prediction of elemental compositions of each analyte with the aid of accurate mass measurement. We have exploited this distinguished mass resolution performance for non-targeted metabolomics studies. As a next challenge to convert information of elemental compositions into chemical structures of metabolites, we introduced the van Krevelen diagram, which is constructed by plotting atomic ratios of H/C versus O/C for each elemental composition, into our FT-ICR/MS-based metabolomics scheme. On the diagram, possible metabolic activities can also be superimposed as to connected data points. Massive amounts of raw data from mass spectrometry operations should be interpreted in a biological context by analysis of changes of elemental compositions due to metabolic activities. In this report, we discuss the possibility of this analytical approach as a general metabolomics tool.
Journal
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- Plant and Cell Physiology Supplement
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Plant and Cell Physiology Supplement 2009 (0), 1021-1021, 2009
The Japanese Society of Plant Physiologists
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Details 詳細情報について
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- CRID
- 1390282680608702592
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- NII Article ID
- 130006993455
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed