Pauson-Khand反応を用いたSkytanthineタイプアルカロイドの不斉全合成研究
書誌事項
- タイトル別名
-
- Synthetic Study of Skytanthine-type Alkaloid by Using Pauson-Khand Reaction
- 公開日
- 2007
- DOI
-
- 10.14895/hannou.33.0.30.0
- 公開者
- 日本薬学会化学系薬学部会
説明
Skytanthine-type alkaloids having an azabicyclo[4.3.0]nonane skeleton as a core framework have been isolated from a number of Tecoma and Skytanthus species. Among them, incarvillateine bearing a characteristic stereochemical feature has been recognized to exhibit significant antinociceptive activity in formaline-induced pain model mice. As part of our continuing effort to synthesize biologically active natural products, we are interested in a diastereoselective synthesis of (-)-incarvilline as a key precursor of (-)-incarvillateine. Delavayine A showing a significant level of antinociceptive activity would also be synthesized by the application of similar methodology. Thus, we decided to exploit an intramolecular Pauson-Khand reaction of the corresponding enyne amide as a key step. We believe that the synthesis developed here should be a useful tool for finding potenthial analgesic compounds.
収録刊行物
-
- 反応と合成の進歩シンポジウム 発表要旨概要
-
反応と合成の進歩シンポジウム 発表要旨概要 33 (0), 30-30, 2007
日本薬学会化学系薬学部会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282680610120064
-
- NII論文ID
- 130006995476
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可