Rh-Catalysed Trifluoromethylation of Ketene Silyl Acetal

DOI

Bibliographic Information

Other Title
  • ケテンシリルアセタールを用いた Rh 触媒 α-CF<SUB>3</SUB> 化反応の開発

Description

We already reported a perfluoroalkylation using ketone silyl enol ethers in the presence of Wilkinson's catalyst to give α-perfluoroalkylated ketones in moderate yields. However, using some perfluoroalkyl halides such as CF3I or C4F9I which have lower boiling points lead to the lower yields, because the reaction needed to heat at 130ºC. As solve the problem, we examined the various conditions of α-trifluoromethylation, and found that the addition of Et2Zn into the reaction mixture improved the yield of α-CF3 ketones. Furthermore, this condition could apply not only ketone silyl enol ethers but also ketene silyl acetals to give α-CF3 esters in moderate to good yields.

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Keywords

Details 詳細情報について

  • CRID
    1390282680610172160
  • NII Article ID
    130006995550
  • DOI
    10.14895/hannou.33.0.90.0
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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