スルホンアミド及びアミノメチル架橋を有するヘリセンオリゴマーの合成と会合
書誌事項
- タイトル別名
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- Synthesis and Aggregation of Sulfonamidohelicene and Aminomethylhelicene Oligomers
抄録
Double-helix forming ologomers have attracted much interest. However, the relationship between the primary structure and the double-helix forming ability is not well understood. We synthesized and examined aggregation of sulfonamidohelicene oligomers (M)-1 and aminomethylhelicene oligomers (P)-2 in order to compare their property with ethynylhelicene and amidohelicene oligomers previously obtained. (M)-1 (n = 2-7, 9, 11) were synthesized by stepwise method of coupling reaction with building block and deprotection of Boc moieties. (P)-2 (n = 2-5) were obtained by repeating a reductive amination and deprotection of Boc moieties. CD spectra of tetramer (M)-1 (n = 4) and pentamer (P)-2 (n = 5) exhibited a strong cotton effect in m-difluorobenzene. Vapor pressure osmometry in m-difluorobenzene showed bimolecular formation. These results indicated that both formed helix dimer structures.
収録刊行物
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- 反応と合成の進歩シンポジウム 発表要旨概要
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反応と合成の進歩シンポジウム 発表要旨概要 37 (0), 63-63, 2011
日本薬学会化学系薬学部会
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詳細情報 詳細情報について
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- CRID
- 1390282680610227584
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- NII論文ID
- 130006995628
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可