エクチナサイジン743の合成研究
書誌事項
- タイトル別名
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- Synthetic Studies on Ecteinascidin 743
説明
Ecteinascidin 743 (ET 743) is an extremely potent antitumor agent isolated from a marine tunicate, Ecteinascida turbinate. ET 743 is currently undergoing phase II/III clinical trials in Europe and the United States. The novel structural features, poor availability from the natural sources, and the unique mechanism of action have made ET 743 a very attractive target for synthetic chemists. To date, total syntheses have been completed by Corey, Danishefsky, Zhu, and ourselves. We report herein a formal total synthesis of ET 743, featuring a regio- and stereoselective Pictet-Spengler reaction to afford the tetahydroisoquinoline and a diastereoselective Mannich-type reaction of the iminolactone. We have succeeded in the efficient construction of the bicyclo[3.3.1] skeleton from the Mannich-type reaction product.
収録刊行物
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- 反応と合成の進歩シンポジウム 発表要旨概要
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反応と合成の進歩シンポジウム 発表要旨概要 33 (0), 66-66, 2007
日本薬学会化学系薬学部会
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詳細情報 詳細情報について
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- CRID
- 1390282680610237568
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- NII論文ID
- 130006995642
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
