イミニウムイオンのFriedel-Crafts環化による含窒素８、９員環の合成
書誌事項
- タイトル別名
-
- Novel Synthetic Methods of Eight- and Nine-Membered Cyclic Amine Derivatives Based on Friedel-Crafts Reaction via Iminium Ion
説明
The Pictet-Spengler reaction is one of the most useful methods for synthesizing tetrahydroisoquinoline. This reaction is a kind of Friedel-Crafts reaction. We found that an intramolecular Friedel-Crafts reaction of the iminium cation afforded eight- and nine-membered cyclic amines fused with a benzene ring in high yield. Treatment of sulfonamide derivatives with an aromatic ring possessing one or two methyl groups with TMSOTf gave 1,2,3,4,5,6-hexahydrobenzo[c]azocine derivatives in high yields. Moreover, when sulfonamide derivatives having an acetylene cobalt complex moiety were subjected to the same conditions, not only eight-membered cyclic amine but also nine-membered cyclic amine was obtained in high yield.
収録刊行物
-
- 反応と合成の進歩シンポジウム 発表要旨概要
-
反応と合成の進歩シンポジウム 発表要旨概要 32 (0), 38-38, 2006
日本薬学会化学系薬学部会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282680610544512
-
- NII論文ID
- 130006995986
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可