銅触媒を用いる2-エチニルアニリンとグリオキシル酸エステルからの 新規キノリン骨格構築法の開発
書誌事項
- タイトル別名
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- Development of a novel construction of a quinoline skeleton from a 2-ethynylaniline and a glyoxylate ester by a copper catalyst
説明
2-Ethynylanilines are one of the most useful building-blocks for preparation of nitrogen-containing heterocycles, such as indoles and quinolines. We have already reported that a sort of terminal substituent on the triple bond on a 2-ethynylaniline selectively produces indoles and quinolines.<BR> Ongoing our research on the line, we have found that a catalytic amount (10 mol%) of CuBr2 promoted intermolecular cyclization of 2-ethynylanilines with N,O-acetals to produce a variety of quinoline derivatives in practical yields. These results showed a methine carbon on the N,O-acetal was embedded as a new carbon moiety in the quinoline skeleton. We have also developed a single-step synthesis of the quinoline derivative by the reaction of the 2-ethynylaniline with ethyl glyoxylate in the presence of piperidine and CuBr2.
収録刊行物
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- 反応と合成の進歩シンポジウム 発表要旨概要
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反応と合成の進歩シンポジウム 発表要旨概要 37 (0), 118-118, 2011
日本薬学会化学系薬学部会
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詳細情報 詳細情報について
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- CRID
- 1390282680610612352
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- NII論文ID
- 130006996072
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
