不斉ロジウム触媒による環状エノンの高エナンチオ、位置選択的水素化反応
書誌事項
- タイトル別名
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- Highly Enantio- and <I>s</I>-<I>trans</I> C-C Double Bond Selective Catalytic Hydrogenation of Cyclic Enones
説明
Enantioselective hydrogenation is one of the most powerful and practical methods in asymmetric catalytic reactions. Enantioselective hydrogenation of C–C double bond in enones, however, has not been well studied despite usefulness of the resulting chiral ketones. Several efficient methods using enantioselective hydrosilylation have been reported. In terms of atom-economy and environmental concerns, however, development of efficient catalytic asymmetric hydrogenation is highly desirable.<BR>Herein we report highly enantioselective and s-trans C-C double bond selective catalytic asymmetric hydrogenation of piperitenone with extremely high catalyst turnover. Existence of s-cis C-C double bond is pivotal to achieve superior levels of enantioselectivity. Moreover, drastic ligand and halide effects were observed, in which s-trans selectivity was completely changed to s-cis selectivity.
収録刊行物
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- 反応と合成の進歩シンポジウム 発表要旨概要
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反応と合成の進歩シンポジウム 発表要旨概要 33 (0), 135-135, 2007
日本薬学会化学系薬学部会
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詳細情報 詳細情報について
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- CRID
- 1390282680610634368
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- NII論文ID
- 130006996106
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
