HIV侵入の動的超分子機構を模倣した立体構造特異的人工抗原分子の創製

DOI

書誌事項

タイトル別名
  • Remodeling of Dynamic Structures of HIV Envelope Proteins and Chemical Synthesis of Artificial Antigen Molecules Inducing Neutralizing Antibodies

説明

The membrane-fusion mechanism involved during entry into the cell of HIV-1 is mediated by envelope proteins (gp120/gp41) and receptors on the target cells (CD4/CCR5/CXCR4). A novel equivalently branched template with C3-symmetric linkers was designed and synthesized. Our synthetic antigen mimicking the N36 trimeric form was synthesized using this template. The antiserum produced by immunization of the N36 trimeric form antigen showed structural preference in binding to the N36 trimer. Furthermore, it was revealed that the antiserum has stronger inhibitory activity against HIV-1 infection than that induced by the N36 monomer. The present results suggest HIV vaccine design based on relationships to the natural structures of proteins involved in HIV fusion mechanisms is highly effective.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390282680611600768
  • NII論文ID
    130006997361
  • DOI
    10.14895/hannou.36.0.164.0
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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