抗腫瘍活性ナフトキノンモノオキシム系化合物の化学
書誌事項
- タイトル別名
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- Chemistry of Antitumor Active 2-Aryl-1,4-naphthoquinone-1-oximes
説明
It is known that some benzophenanthridine alkaloids show antitumor activity. We also found that a 2-aryl-1,4-napthoquinone-1-oxime, which was prepared as a key synthetic intermediate for macarpine, a 12-alkoxybenzophenanthridine base, by the regioselective nitrosation of 3-aryl-1-naphthol under basic conditions (isoamyl nitrite–potassium carbonate–DMF), showed strong antitumor activity. Thus, the structure–activity relationship of the naphthoquinone monooxime derivatives was examined for the development of a new anticancer drug. Chemical modification of the naphthoquinone skeleton suggested that the quinine oxime function was essential for the activity, whereas the substitution system of the 2-aryl group was tolerant.
収録刊行物
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- 反応と合成の進歩シンポジウム 発表要旨概要
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反応と合成の進歩シンポジウム 発表要旨概要 30 (0), 240-241, 2004
日本薬学会化学系薬学部会
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- CRID
- 1390282680611602432
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- NII論文ID
- 130006997363
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- データソース種別
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- JaLC
- CiNii Articles
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