抗腫瘍活性ナフトキノンモノオキシム系化合物の化学

書誌事項

タイトル別名
  • Chemistry of Antitumor Active 2-Aryl-1,4-naphthoquinone-1-oximes

説明

It is known that some benzophenanthridine alkaloids show antitumor activity. We also found that a 2-aryl-1,4-napthoquinone-1-oxime, which was prepared as a key synthetic intermediate for macarpine, a 12-alkoxybenzophenanthridine base, by the regioselective nitrosation of 3-aryl-1-naphthol under basic conditions (isoamyl nitrite–potassium carbonate–DMF), showed strong antitumor activity. Thus, the structure–activity relationship of the naphthoquinone monooxime derivatives was examined for the development of a new anticancer drug. Chemical modification of the naphthoquinone skeleton suggested that the quinine oxime function was essential for the activity, whereas the substitution system of the 2-aryl group was tolerant.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390282680611602432
  • NII論文ID
    130006997363
  • DOI
    10.14895/hannou.30.0.240.0
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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