Sodium Orthovanadate, a Potentially Effective Mitigator of Damage after Total-Body Irradiation in Mice

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  • オルトバナジン酸ナトリウム（バナデート）は、マウスにおいて全身照射後の障害に対して有効な緩和剤（Mitigator）である

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Abstract

Sodium orthovanadate (Na3VO4, vanadate), an inorganic vanadium compound, effectively suppresses radiation-induced p53-mediated apoptosis by both transcription-dependent and transcription-independent pathways. As a potent radiation protector administered at a dose of 20 mg/kg prior to total-body irradiation by intraperitoneal injection, it completely protected mice from hematopoietic syndrome and partially from the gastrointestinal syndrome. In the present study, possible radiation mitigation effects were investigated by administration of vanadate after total-body irradiation in mice. Results showed that even a single administration of vanadate at a dose of 20 mg/kg markedly improved the 30-day survival, bone marrow aplasia, the peripheral blood hemogram, and the bone marrow micronucleated erythrocytes in the survivors. When vanadate was administrated at a single dose of 40 mg/kg, or it was continued for 4 consecutive days at a dose of 5 mg/kg per day after a single dose of 20 mg/kg, the efficacy was further significantly improved. The dose reduction factor was 1.3 when a single dose of 40 mg/kg was administrated 15 minutes after total-body irradiation in mice. Together, these findings indicate that vanadate would be a potent mitigator as well as an effective protector of the hematopoietic syndrome induced by total-body irradiation in mice.

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