Involvement of radical damage in the biological effects of high LET radiation

DOI

Bibliographic Information

Other Title
  • 高LET放射線によるラジカル損傷について

Description

Indirect action due to radical damage has been recognized to decrease with increasing LET judging from the decreased yield of OH radicals. However our recent experiments showed significant generation of OH radical mediated damage even in the high LET region from the DMSO protection against cell killing and 8-hydroxy-2'-deoxyguanosine (8-OHdG or 8-oxoG) production in exposed cells. Based on these results with the previous reports using OH radical scavengers, we would like to evaluate the contribution of indirect action in the high LET biological effects. In addition, we also discuss about the mechanism of the characteristic reduction of oxygen effect in the high LET region from the viewpoint of unique radical reactions due to densely produced ionizations in water by high LET radiation.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390282680618364288
  • NII Article ID
    130007001152
  • DOI
    10.11513/jrrsabst.2008.0.87.0
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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